產(chǎn)品名稱(chēng)：anti-mouse Ly-49G2 Purified eBio4D11 (4D11) 500 ug 產(chǎn)品貨號(hào)：eBioscience 14-5781-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse Ly-49G2 Purified Also known as: LGL-1, Ly49G2, Ly49 Clone: eBio4D11 (4D11) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5781 Cat. No. Size 14-5781-85 500 ug 14-5781-81 50 ug 14-5781-82 100 ug Description: The 4D11 monoclonal antibody reacts with Ly-49G2 (also known as LGL-1). The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate recognition domains, which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor. Ly-49G2 is an inhibitory receptor expressed on subsets of natural killer (NK) cells, NK-T cells (in all strains tested), and on a population of memory CD8+ T cells (in C57BL/6 mice). The 4D11 antibody has been reported to cross react with the Ly-49AB6, Ly-49ABALB, and Ly-49T129/J inhibitory receptors and Ly-49LCBA/J activatingreceptors. The proportion of NK-T cells expressing Ly-49A and Ly-49G2 is higher in the thymus than in liver, and there is evidence that down-regulation of Ly-49 receptor expression is necessary for normal NK–T-cell development to occur.
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