產(chǎn)品名稱：Anti-Mouse Ikaros (clone 2A9-mIkaros) Purified, 100 ug 產(chǎn)品貨號：eBioscience 14-5780-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse Ikaros Purified Also known as: IZKF1 Clone: 2A9-mIkaros RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5780 Cat. No. Size 14-5780-80 25 ug 14-5780-82 100 ug Description: This 2A9-mIkaros monoclonal antibody reacts with mouse Ikaros, the 70-kDa founding member of the Ikaros family of C2H2-type zinc finger transcription factors. Ikaros is expressed in hematopoietic progenitor cells, thymocytes, mature T and B cells, monocytes, macrophages, and natural killer cells. This protein has also been shown to be expressed in non-immune cells such as neurons. Studies indicate that Ikaros can interact with other family members, namely Aiolos and Eos. Ikaros is involved in thymocyte development, B cell differentiation, cell cycle control, chromatin remodeling, and tumor suppression. Moreover, Ikaros has been implicated in leukemia and lymphoma. Ikaros has been demonstrated to regulate expression of Tdt, CD8a, and Notch target genes. At least eight Ikaros isoforms exist due to alternative splicing. The 2A9-mIkaros antibody has been reported to recognize Ikaros isoform VI (Ik-6), which is the longest and most predominant.
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