產品名稱：anti-human CCR3 (CD193, CKR3) Purified eBio5E8-G9-B4 (5E8-G9-B4) 100 ug 產品貨號：eBioscience 14-1939-82 產品規(guī)格：500 ug Anti-Human CD193 (CCR3) Purified Also known as: C-C chemokine receptor type 3, CMKBR3 Clone: eBio5E8-G9-B4 (5E8-G9-B4) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-1939 Cat. No. Size 14-1939-80 25 ug 14-1939-82 100 ug Description: The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.
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