產品名稱：anti-mouse CD180 Purified RP/14 500 ug 產品貨號：eBioscience 14-1801-85 產品規(guī)格：500 ug Anti-Mouse CD180 (RP105) Purified Also known as: RP-105, Toll-like Receptor, TLR Family, LY-78 Clone: RP/14 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-1801 Cat. No. Size 14-1801-81 50 ug 14-1801-82 100 ug 14-1801-85 500 ug Description: The RP/14 monoclonal antibody reacts with mouse CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on mature B cells, monocytes/macrophages and dendritic cells. Ligation of RP105 with RP/14 protects B cells from irradiation- or dexamethasone-induced apoptosis, and drives them to proliferate. B cells activated by RP105-ligation arrest their growth and undergo apoptosis when the antigen receptor is engaged. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death.
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