產(chǎn)品名稱：Affinity Purified anti-mouse Lyve-1 (Lymphatic Vessel Endothelial Receptor 1) 100 ug 產(chǎn)品貨號：eBioscience 14-0443-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse Lyve-1 Purified Also known as: Lymphatic Vessel Endothelial Hyaluronan Receptor 1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor Clone: ALY7 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-0443 Cat. No. Size 14-0443-80 25 ug 14-0443-82 100 ug Description: The monoclonal antibody ALY7 recognizes mouse LYVE-1, a transmembrane glycoprotein with similarity to CD44. The extracellular domain contains a conserved hyaluronan binding domain also found in CD44. Expression is found on lymphatic and liver endothelial cells and some populations of macrophages. The lymphatic system is responsible for transporting proteins and cells (especially dendritic cells) to tissues throughout the body, thereby acting as immune surveyors. LYVE-1 is one characteristic protein, along with podoplanin, PROX-1, Tie-2 and VEGFR-3, that is expressed on lymphatic endothelial cells (LECS). The ligand for LYVE-1 is hyaluronan, a large mucopolysaccharide. Although LYVE-1 can bind hyaluronan in vitro, the site for ligand binding in vivo is masked by sialyated O-linked glycan chains. It is postulated that binding to ligand requires modification/unmasking to expose the binding site. The development and remodeling of the endothelium after injury is an area of extensive study. When transplanted, hematopoietic stem cells (HSCs) can give rise to LECs that integrate into the endothelium in normal and metastatic tissue.
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