產(chǎn)品名稱：anti-human CD11b Purified CBRM1/5 500 ug 產(chǎn)品貨號(hào)：eBioscience 14-0113-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD11b (activation epitope) Purified Also known as: Integrin alpha M, ITGAM, Mac-1 alpha (Mac1A), Complement Receptor 3 alpha (CR3A) Clone: CBRM1/5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-0113 Cat. No. Size 14-0113-81 50 ug 14-0113-82 100 ug 14-0113-85 500 ug Description: The CBRM1/5 monoclonal antibody reacts with an activation-specific epitope of human Mac-1. CBRM1/5 binds a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorbol esters but does not recognize Mac-1 on resting myeloid cells. Through interactions with its ligands, Mac-1 participates in adhesive cell interactions. The epitope recognized by this mAb localizes to the I domain on the α chain of Mac-1 very close to the ligand binding site in a region that is widely exposed. CBRM1/5 blocks Mac-1 dependent adhesion to fibrinogen and ICAM-1 and inhibits chemoattractant-stimulated adhesion of eosinophils to the Intercellular Adhesion Molecule-1 (ICAM-1). It should be noted that low level activation may occur during processing of freshly drawn blood. Therefore the CBRM1.5 antibody may exhibit some binding to Mac-1 in these unstimulated samples. However, higher levels of Mac-1 expression are observed in activated samples when compared to unstimulated cells.
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