產(chǎn)品名稱：anti-mouse TWEAK Biotin MTW-1 500 ug 產(chǎn)品貨號：eBioscience 13-9913-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD255 (TWEAK) Biotin Also known as: TNF-related weak inducer of apoptosis, APO3L Clone: MTW-1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-9913 Cat. No. Size 13-9913-81 50 ug 13-9913-82 100 ug 13-9913-85 500 ug Description: The MTW-1 monoclonal antibody reacts with mouse TWEAK, a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many ***** and fetal tissues. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor (Fn14, TWEAK-R) promotes secretion of IL-8, activation of NF-κB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF, it is generally less effective in inducing apoptosis, giving rise to its name, TNF-like weak inducer of apoptosis.
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