產(chǎn)品名稱：anti-human c-Met (HGFR) Biotin eBioclone 97 25 ug 產(chǎn)品貨號：eBioscience 13-8858-80 產(chǎn)品規(guī)格：25 ug Anti-Human c-Met (HGF Receptor) Biotin Also known as: hepatocyte growth factor receptor Clone: eBioclone 97 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-8858 Cat. No. Size 13-8858-80 25 ug Description: 97 monoclonal antibody was generated against a human c-Met-Ig fusion protein, and reacts with human c-Met (HGFR)-transfected cells. Human c-Met is a 145 kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma;. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.
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