產(chǎn)品名稱：Biotin anti-mouse/human integrin beta7 25 ug 產(chǎn)品貨號(hào)：eBioscience 13-5867-80 產(chǎn)品規(guī)格：25 ug Anti-Human/Mouse Integrin beta 7 Biotin Also known as: Integrin b7, ITGB7 Clone: FIB504 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-5867 Cat. No. Size 13-5867-80 25 ug 13-5867-82 100 ug Description: The FIB504 monoclonal antibody reacts with human and mouse integrin β7. Integrin β7 is a 130 kD glycoprotein which associates with integrin α4 (CD49d) to form the α4β7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with αE (CD103) to form the αEβ7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin α4β7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin αEβ7 is E-cadherin (CD324). Integrin β7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.
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