產(chǎn)品名稱：anti-human Foxp3 Biotin PCH101 100 ug 產(chǎn)品貨號：eBioscience 13-4776-82 產(chǎn)品規(guī)格：100 ug Anti-Human Foxp3 Biotin Also known as: Forkhead Box P3, Scurfin, JM2, Treg Clone: PCH101 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-4776 Cat. No. Size 13-4776-82 100 ug 13-4776-80 25 ug Description: eBioscience offers a panel of monoclonal antibodies to different epitopes of human Foxp3, providing useful tools for investigating the complete expression pattern of Foxp3 at the protein level, and discerning the precise subsets of Foxp3+ cells. Please contact tech@ebioscience.com or 888.810.6168 for any additional assistance. The PCH101 antibody reacts with the amino terminus of human foxp3 protein also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in ‘scurfy’ (sf) mice. Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. Intracellular staining of human peripheral blood mononuclear cells (PBMCs) with PCH101 antibody using the anti-human Foxp3 Staining Set and protocol reveals approximately 0.5-4% of lymphocytes staining, with the majority of staining occurring in the CD25bright population. This is subject to donor variability. PCH101 crossreacts with rhesus, chimpanzee and cynomolgus. We recommend the use of CD4 (OKT4, cat. 11-0048, or RPA-T4, cat. 11-0049, depending on the species) and CD25 (BC96, cat. 17-0259).
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