產(chǎn)品名稱：Mouse Jagged-2 (clone HMJ2-1), 25 ug 產(chǎn)品貨號：eBioscience 13-3392-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse Jagged 2 Biotin Also known as: JAG2 Clone: HMJ2-1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-3392 Cat. No. Size 13-3392-80 25 ug 13-3392-82 100 ug Description: This HMJ2-1 monoclonal antibody reacts with mouse Jagged-2, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Jagged-2 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-2 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. Note: Staining of endogenous splenic dendritic (CD8+CD11c+) cells could only be consistently confirmed in cells isolated from C57BL/6, but not Balb/c, mice. Other strains have not been tested. The antiobdy has been reported to crossreact to rat and have blocking function.
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