產(chǎn)品名稱：Biotin Human CNTFR alpha (clone AN-D3), 25 tests 產(chǎn)品貨號：eBioscience 13-1304-80 產(chǎn)品規(guī)格：25 tests Anti-Human Ciliary Neurotrophic Factor Receptor alpha Biotin Also known as: CNTFRa, CNTF Receptor alpha, CNTF Ra Clone: AN-D3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 13-1304 Cat. No. Size 13-1304-80 25 ug 13-1304-82 100 ug Description: This AN-D3 monoclonal antibody reacts with human ciliary neurotrophic factor receptor alpha (CNTFR alpha). CNTFR alpha expression is primarily localized to the nervous system and skeletal muscle. Together with gp130 and LIFR beta, this molecule forms the tripartite CNTF receptor complex. These receptor components remain unassociated until CNTF binds CNTFR alpha, which leads to their recruitment. Subsequent activation of the JAK-STAT pathway leads to changes in gene expression that affect cell survival and differentiation. More recently, another cytokine, neuropoietin, has been shown to bind the CNTFR receptor complex to promote nervous system development. The AN-D3 antibody recognizes CNTFR alpha when it is dissociated from the tripartite complex.
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