eBioscience 12-9917-41 anti-human Toll-like receptor 4 (CD284) PE HTA125 25 tes

產品名稱：anti-human Toll-like receptor 4 (CD284) PE HTA125 25 tests
產品貨號：eBioscience 12-9917-41
產品規格：25 tests
Anti-Human CD284 (TLR4) PE
Also known as: TLR-4, toll-like receptor 4
Clone: HTA125
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9917
Cat. No. Size
12-9917-41  25 tests 
12-9917-42  100 tests 
Description: The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (~100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors.
 

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