產(chǎn)品名稱：anti-mouse TWEAK PE MTW-1 50 ug 產(chǎn)品貨號(hào)：eBioscience 12-9913-81 產(chǎn)品規(guī)格：50 ug Anti-Mouse CD255 (TWEAK) PE Also known as: TNF-related weak inducer of apoptosis, APO3L Clone: MTW-1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-9913 Cat. No. Size 12-9913-81 50 ug 12-9913-82 100 ug 12-9913-83 200 ug Description: The MTW-1 monoclonal antibody reacts with mouse TWEAK, a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many ***** and fetal tissues. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor (Fn14, TWEAK-R) promotes secretion of IL-8, activation of NF-κB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF, it is generally less effective in inducing apoptosis, giving rise to its name, TNF-like weak inducer of apoptosis.
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