eBioscience 12-9829-41 Anti-Human LAP (Latency Associated Peptide) PE (FNLAP) 2

產品名稱：Anti-Human LAP (Latency Associated Peptide) PE (FNLAP) 25 tests
產品貨號：eBioscience 12-9829-41
產品規格：25 tests
Anti-Human LAP (Latency Associated Peptide) PE
Also known as: Pro-TGF beta 1, LAP/TGF beta 1
Clone: FNLAP
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9829
Cat. No. Size
12-9829-41  25 tests 
12-9829-42  100 tests 
Description: The FNLAP monoclonal antibody reacts with human latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.
 

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