eBioscience 12-9201-42 Anti-Human CD200R PE (OX108) 100 tests

產品名稱：Anti-Human CD200R PE (OX108) 100 tests
產品貨號：eBioscience 12-9201-42
產品規格：100 tests
Anti-Human CD200 Receptor PE
Also known as: CD200R, ox-2R, CD200 receptor
Clone: OX108
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9201
Cat. No. Size
12-9201-41  25 tests 
12-9201-42  100 tests 
Description: The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs.
Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.
 

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