產(chǎn)品名稱(chēng)：anti-mouse Toll-like receptor 4 (CD284) PE UT41 25 ug 產(chǎn)品貨號(hào)：eBioscience 12-9041-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse CD284 (TLR4) PE Also known as: TLR-4, toll-like receptor 4 Clone: UT41 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-9041 Cat. No. Size 12-9041-80 25 ug Description: The UT41 monoclonal antibody was generated against BaF3 cells overexpressing mouse TLR4. So far, at least twelve members of the Toll family have been identified. This family of type I transmembrane protein is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4, which is approximately 100 kDa, is expressed by myeloid lineage cells. The MTS510 monoclonal antibody co-immunoprecipitates MD-2 (~30 kDa) and TLR4 (~100 kDa), and preferentially reacts with TLR4 that is associated with MD-2. In comparison, binding of the UT41 monoclonal antibody occurs with and without formation of the TLR4/MD-2 complex . Please contact eBioscience Technical Support for further information.
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