eBioscience 12-7823-41 Anti-Human IL-23 p19 PE (23dcdp) 25 tests

產品名稱：Anti-Human IL-23 p19 PE (23dcdp) 25 tests
產品貨號：eBioscience 12-7823-41
產品規格：25 tests
Anti-Human IL-23 p19 PE
Also known as: Interleukin-23 p19
Clone: 23dcdp
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-7823
Cat. No. Size
12-7823-41  25 tests 
12-7823-42  100 tests 
Description: This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORγt expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells.
Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as agonists of the β-glucan receptor, Dectin-1. Our studies suggest donor, kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
 

產品留言

標題

聯系人

聯系電話

內容

驗證碼

點擊換一張

注：1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!