eBioscience 12-6695-42 Anti-Mouse/Human ZAP-70 PE (1E7.2) 100 tests

產品名稱：Anti-Mouse/Human ZAP-70 PE (1E7.2) 100 tests
產品貨號：eBioscience 12-6695-42
產品規格：100 tests
Anti-Human/Mouse ZAP-70 PE
Also known as: ZAP70
Clone: 1E7.2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-6695
Cat. No. Size
12-6695-73  100 tests 
12-6695-80  25 ug 
12-6695-82  100 ug 
12-6695-42  100 tests 
Description: The 1E7.2 antibody reacts with human and mouse ZAP-70, the TCRζ-associated protein-70. ZAP-70 is a cytosolic protein tyrosine kinase (PTK) and a member of the Syk family of proteins. It is expressed in T and NK cells and is required for TCR signaling and development. ZAP-70 interacts with the TCR complex by binding to tyrosine-phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) present in the invariant subunits of the TCR complex. Following activation, ZAP-70 is phosphorylated on several tyrosine residues by two mechanisms; an autophosphorylation and a transphosphorylation by the Src family tyrosine kinase Lck1-3. Tyrosine phosphorylation of ZAP-70 correlates to its increased kinase activity and triggers downstream signaling events. Mutations in ZAP-70 have been shown to result in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. 1E7.2 was generated against a KLH-peptide sequence corresponding to the human ZAP-70 amino acid residues 282-307. While ZAP-70 is normally expressed in T and NK cells, several recent studies have also shown high correlation of ZAP-70 positive expression with mutated IgVH expression in B-chronic lymphocytic leukemia (CCL). In conclusion, the expression of ZAP-70, which can be measured by intracellular flow cytometry, may serve as a prognostic marker for B-CLL.
 

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