產(chǎn)品名稱(chēng)：Anti-Mouse KLRG1 / MAFA PE (2F1) 25 ug 產(chǎn)品貨號(hào)：eBioscience 12-5893-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse KLRG1 PE Also known as: MAFA Clone: 2F1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-5893 Cat. No. Size 12-5893-80 25 ug 12-5893-82 100 ug Description: This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.
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