eBioscience 12-5785-80 anti-Notch-1 PE mN1A 25 ug

產品名稱：anti-Notch-1 PE mN1A 25 ug
產品貨號：eBioscience 12-5785-80
產品規格：25 ug
Anti-Human/Mouse Notch1 PE
Also known as: Notch-1, TAN1, Motch, Neurogenic locus notch homolog protein 1
Clone: mN1A
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5785
Cat. No. Size
12-5785-80  25 ug 
12-5785-82  100 ug 
Description: The Notch family of transmembrane receptors controls cell-fate decisions during the development of many organs in a wide variety of species. After binding its ligand, the Notch receptor is cleaved in its transmembrane domain, and the resulting intracellular domain dissociates from the membrane and translocates to the nucleus, where it is able to suppress the expression of lineage-specific genes by interacting with transcriptional repressors. The mN1A antibody reacts with the intracellular domain of mouse and human Notch1, but not with Notch2, 3, or 4. The mN1A antibody has a low affinity for the full-length (unprocessed or heterodimeric cell surface) forms of Notch1. In the mouse, Notch mRNA is expressed in mouse hematopoietic cells of the fetal liver and ***** thymus and bone marrow. In the thymus, Notch1 protein is detected in CD4-CD8- (double-negative) and CD4-CD8+ (single-positive) thymocytes. Studies of Notch1-transgenic cells and Notch1-null mice indicate that the receptor is involved in the regulation of lymphopoiesis and myelopoiesis.
 

產品留言

標題

聯系人

聯系電話

內容

驗證碼

點擊換一張

注：1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!