eBioscience 12-5767-82 Mouse Delta-like 1 (clone HMD1-5), 100 ug

產品名稱：Mouse Delta-like 1 (clone HMD1-5), 100 ug
產品貨號：eBioscience 12-5767-82
產品規格：100 ug
Anti-Mouse DLL1 (delta-like 1) PE
Also known as: DL1
Clone: HMD1-5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5767
Cat. No. Size
12-5767-80  25 ug 
12-5767-82  100 ug 
Description: The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis.
 

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