eBioscience 12-5498-41 Anti-Human TSLP Receptor PE eBio1D8 (1D8) 25 tests

產品名稱：Anti-Human TSLP Receptor PE eBio1D8 (1D8) 25 tests
產品貨號：eBioscience 12-5498-41
產品規格：25 tests
Anti-Human TSLP Receptor PE
Also known as: thymic stromal derived lymphopoietin receptor, CRLF-2
Clone: eBio1D8 (1D8)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5498
Cat. No. Size
12-5498-41  25 tests 
12-5498-42  100 tests 
Description: The eBio1D8 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR). TSLPR is an approximately 50 kDa protein with significant similarity to the common γ-chain (CD132). TSLPR complexes with IL-7R alpha (CD127) to form the high affinity receptor that binds thymic stromal-derived lymphopoietin (TSLP). Human TSLPR is expressed by monocytes and CD11c+ dendritic cells, and TSLP binding induces the expression of the Th2 cell-attracting chemokines CCL17 and CCL22. Furthermore, the TSLPR-induced activation of dendritic cells indirectly results in the increased secretion of Th2 cytokines IL-4, -5 and -13, which may be necessary for the regulation of CD4+ T cell homeostasis. In mice, deficiency of TSLPR has no effect on lymphocyte numbers, whereas double deficiency of TSLPR and common γ-chain results in fewer lymphocytes than seen in mice deficient in the common gamma-chain alone. The eBio1D8 monoclonal antibody is able to cross-block binding of another anti-human TSLPR monoclonal antibody, eBio1A6.
 

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