eBioscience 12-1939-41 Anti-Human CD193 (CCR3, CKR3) PE (5E8-G9-B4) 25 tests

產品名稱：Anti-Human CD193 (CCR3, CKR3) PE (5E8-G9-B4) 25 tests
產品貨號：eBioscience 12-1939-41
產品規格：25 tests
Anti-Human CD193 (CCR3) PE
Also known as: C-C chemokine receptor type 3, CMKBR3
Clone: eBio5E8-G9-B4 (5E8-G9-B4)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-1939
Cat. No. Size
12-1939-41  25 tests
12-1939-42  100 tests 
Description: The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.
 

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