產(chǎn)品名稱：Anti-Mouse CD185 (CXCR5) (polyclonal) PE , 25 ug 產(chǎn)品貨號：eBioscience 12-1851-80 產(chǎn)品規(guī)格：25 ug Anti-Mouse CD185 (CXCR5) PE (To Be Discontinued. Please refer to clone SPRCL5 (Cat. No. 12-7185)) Also known as: C-X-C Chemokine Receptor Type 5 Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-1851 Cat. No. Size 12-1851-80 25 ug Description: This polyclonal antibody reacts with Mouse CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CXCR5 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. CXCR5+ circulating T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CXCR5 is expressed on nearly all CD4+ cells, including follicular helper T cells, along with CD45RO and such activation markers as CD69 and ICOS. These cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CXCR5 an established marker of follicular helper T cells.
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