eBioscience 12-1831-80 anti-mouse CD183 (CXCR3) PE CXCR3-173 25 ug

產品名稱：anti-mouse CD183 (CXCR3) PE CXCR3-173 25 ug
產品貨號：eBioscience 12-1831-80
產品規格：25 ug
Anti-Mouse CD183 (CXCR3) PE
Also known as: C-X-C chemokine receptor type 3, IP-10 receptor
Clone: CXCR3-173
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-1831
Cat. No. Size
12-1831-80  25 ug
12-1831-82  100 ug 
Description: The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.
The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.
 

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