eBioscience 12-1528-41 Anti-Human CD152 PE (20A, A3) 25 tests

產品名稱：Anti-Human CD152 PE (20A, A3) 25 tests
產品貨號：eBioscience 12-1528-41
產品規格：25 tests
Anti-Human CD152 (CTLA-4) PE
Also known as: CTLA4
Clone: eBio20A (20A, A3)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-1528
Cat. No. Size
12-1528-41  25 tests 
12-1528-42  100 tests 
Description: The eBio20A monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.
 

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