產(chǎn)品名稱：anti-rat CD152 PE WKH203 25 ug 產(chǎn)品貨號：eBioscience 12-1520-80 產(chǎn)品規(guī)格：25 ug Anti-Rat CD152 (CTLA-4) PE Also known as: CTLA4, Ly-56 Clone: WKH203 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-1520 Cat. No. Size 12-1520-80 25 ug 12-1520-82 100 ug Description: The WKH203 monoclonal antibody reacts with rat CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.
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