eBioscience 12-0938-42 Anti-Human CD93 PE (R3) 100 tests

產品名稱：Anti-Human CD93 PE (R3) 100 tests
產品貨號：eBioscience 12-0938-42
產品規格：100 tests
Anti-Human CD93 PE
Also known as: C1qRp, C1q Receptor, C1qR
Clone: R3
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-0938
Cat. No. Size
12-0938-41  25 tests 
12-0938-42  100 tests 
Description: The monoclonal antibody R3 recognizes human CD93, also known as C1qRp. The glycoprotein CD93 binds to C1q, the subunit of the complement protein, mannose binding lectin and pulmonary surfactant protein A. CD93 is predicted to play a role in the clearance of apoptotic cells. Expression of CD93 is confined to myeloid cells with higher expression on monocytes than neutrophils, eosinophils, platelets and endothelial cells. Expression on DC’s is downregulated upon maturation. Additionally, CD93 has been shown to define an early bone marrow stem cell population of hematopoietic and hepatic precursors.
The R3 antibody has been shown to have activating function by increasing phagocytosis when presented in an immobilized state and inhibitory functions when presented in a soluble state. CD93 can be shed from the cell surface. This phenomenon can be measures using R3 antibody as detection with R139 as capture to detect soluble CD93 by ELISA. The epitope for R3 lies in the CRD domain.\\The R3 antibody has been shown to have activating function by increasing phagocytosis when presented in an immobilized state and inhibitory functions when presented in a soluble state. CD93 can be shed from the cell surface. This phenomenon can be measures using R3 antibody as detection with R139 as capture to detect soluble CD93 by ELISA. The epitope for R3 lies in the CRD domain.
 

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