eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests
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產品名稱: eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests
產品型號: 12-0748-41
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eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests
eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests
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eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests
產品名稱：Anti-Human CD74 (clone 5-329) PE, 25 tests
產品貨號：eBioscience 12-0748-41
產品規格：25 tests
Anti-Human CD74 PE
Also known as: Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration InhibitoryFactor
Clone: 5-329
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-0748
Cat. No. Size
12-0748-41 25 tests
12-0748-42 100 tests
Description: This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43 kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NF\kappaB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.
