產(chǎn)品名稱：anti-human CD40 PE 5C3 25 tests 產(chǎn)品貨號：eBioscience 12-0409-41 產(chǎn)品規(guī)格：25 tests Anti-Human CD40 PE Also known as: TNFRSF5 Clone: 5C3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 12-0409 Cat. No. Size 12-0409-41 25 tests 12-0409-42 100 tests Description: The 5C3 monoclonal antibody reacts with human CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development and maturation by inducing Ig isotype-switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. 5C3 is reported to be used for activation of B cells in in vitro functional assays.
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