產品名稱：Anti-Helios (clone 22F6) FITC, 25 ug 產品貨號：eBioscience 11-9883-80 產品規(guī)格：25 ug Anti-Helios FITC Also known as: Ikaros family zinc finger 2, IKZF2 Clone: 22F6 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 11-9883 11-9883-80 25 ug 11-9883-82 100 ug Description: This 22F6 monoclonal antibody reacts with human, mouse and canine Helios. Helios is a zinc-finger transcription factor first identified for its similarity to Ikaros. It is expressed in hematopoietic stem cells in both the embryo and ***** mice. While the highest expression is found in regulatory T cells, Helios is not expressed in mature B cells, dendritic cells or myeloid cells. Helios can form a homodimer as well as heterodimerize with other Ikaros family members to regulate transcription. Eight isoforms of Helios exist, some of which possess a dominant-negative function that has also been found to be upregulated in lymphoid malignancies, including T-acute lymphoblastic leukemia.
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