產(chǎn)品名稱：anti-human SLP-76 FITC HS76 25 tests 產(chǎn)品貨號(hào)：eBioscience 11-7769-71 產(chǎn)品規(guī)格：25 tests Anti-Human SLP-76 FITC Also known as: SLP76, SLP-76 tyrosine phosphoprotein, Lymphocyte cytosolic protein 2, LCP2 Clone: HS76 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 11-7769 11-7769-71 25 tests Description: The HS76 antibody reacts with human SLP-76. SLP-76 (SH2 domain-containing leukocyte protein of 76 kD) has also been described as lymphocyte cytosolic protein 2 (LCP2 ) and 76-kDa phosphoprotein (pp76 ). SLP-76 is a cytosolic adaptor protein expressed in several cell types of hematopoietic origin. SLP-76 associates with a number of additional molecules and is required for coupling receptor ligation with more distal signaling events in immature thymocytes, mature T cells, platelets, and mast cells. SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
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