Anti-Human ILT4 (CD85d) blocking FITC **

產品名稱：Anti-Human ILT4 (CD85d) blocking FITC (27D6) 100 tests
產品貨號：eBioscience 11-5148-42
產品規格：100 tests
Anti-Human CD85d (ILT4) FITC
Also known as: ILT-4, LIR2, LILRB2, MIR10
Clone: 27D6
RUO: For Research Use Only. Not for use in diagnostic
procedures.
SKU# 11-5148
Cat. No. Size
11-5148-41  25 tests 
11-5148-42  100 tests 
Description: The monoclonal antibody 27D6 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leuokocyte Ig-like receptor) MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor containing 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection.
The monoclonal antibody 27D6 has been shown to block binding of ligand (HLA-G tetramer). 
 

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