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Anti-Mouse AIRE Purified (5H12) **

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產品名稱: Anti-Mouse AIRE Purified (5H12) **
產品型號: 14-5934-82
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Anti-Mouse AIRE Purified (5H12) **


Anti-Mouse AIRE Purified (5H12) **  的詳細介紹
Anti-Mouse AIRE Purified (5H12) **

產品名稱:Anti-Mouse AIRE Purified (5H12) 100 ug
產品貨號:eBioscience 14-5934-82
產品規格:100 ug
Anti-Mouse AIRE Purified
Also known as: Autoimmune Regulator
Clone: 5H12
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5934
Cat. No. Size
14-5934-80  25 ug 
14-5934-82  100 ug 
Description: This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58-kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.
The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.

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