Affinity Purified anti-mouse Bim **

產品名稱：Affinity Purified anti-mouse Bim (Ham 151-149) 100 ug
產品貨號：eBioscience 14-5834-82
產品規格：100 ug
Anti-Mouse Bim Purified
Also known as: Bcl2-like 11, BCL2L11, Bcl2 interacting protein
Clone: Ham151-149
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5834
Cat. No. Size
14-5834-80  25 ug 
14-5834-82  100 ug 
Description: The monoclonal antibody Ham151-149 recognizes mouse Bim, a pro-apoptotic protein belonging to the Bcl-2 family. Bim initiates apoptosis through interactions with other Bcl-2 proteins via the BH3 domain. Transgenic animals suggest a role for Bim in regulating negative selection in the thymus. Additionally, Bim and IL-7 levels are critical for the survival and development of B lymphocytes; Bim expression is upregulated during development. This is consistent with studies of mice lacking Bim, which show an increase in the number of mature B and myeloid cells. Expression of Bim is widespread; hematopoietic, epithelial, germ line and neuronal cells express this protein. Several splice variants have been identified and shown to have varying levels of functionality. Finally, Bim can be phosphorylated resulting in increased apoptotic activities.

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