Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,環(huán)胞霉素A,CsA, Cs-A, CY-A, Sandim
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產(chǎn)品名稱: Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,環(huán)胞霉素A,CsA, Cs-A, CY-A, Sandim
產(chǎn)品型號: Sigma C3662 5mg
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關文檔
簡單介紹
Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,環(huán)胞霉素A,CsA, Cs-A, CY-A, Sandimmune
Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,環(huán)胞霉素A,CsA, Cs-A, CY-A, Sandim
的詳細介紹
Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,環(huán)胞霉素A,CsA, Cs-A, CY-A, Sandimmune
環(huán)胞霉素A
中文名:環(huán)孢多肽A;環(huán)孢靈;環(huán)孢霉素A;賽斯平;山地明 ,環(huán)孢素,新山地明,環(huán)孢素A
英文名:Ciclosporin A ,CsA, Cs-A, CY-A, Sandimmune, Ciclosporin, Cyspin.
Sigma相關產(chǎn)品資料:
Sigma C3662 Cyclosporin A
from Tolypocladium inflatum, ≥95% (HPLC), solid
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Synonym:
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Antibiotic S 7481F1, Cyclosporine
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CAS Number:
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59865-13-3
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Linear Formula:
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C62H111N11O12
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Molecular Weight:
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1202.61
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Beilstein Registry Number:
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3647785
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MDL number:
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MFCD00274558
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PubChem Substance ID:
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24278028
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Description
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Biochem/physiol Actions
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A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
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Properties
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biological source
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from Tolypocladium inflatum
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assay
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≥95% (HPLC)
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form
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solid
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color
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white
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solubility
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dichloromethane: 10 mg/mL
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ethanol: 10 mg/mL
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DMSO: 50 mg/mL
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chloroform: 6 mg/mL
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H2O: insoluble
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Gene Information
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human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)
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storage temp.
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2-8°C
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Safety
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Personal Protective Equipment
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Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
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Hazard Codes
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T
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Risk Statements
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45-60-22
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Safety Statements
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53-45
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WGK Germany
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3
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RTECS
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GZ4120000
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References
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reference
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Donjerkovic, et al., Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium. Cell. Growth Differ. 10, 695-704, (1999)
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Mordvinov, et al., A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. J. Immunol. Methods 228, 163-168, (1999)
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Zaidan, et al., Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J. Neurochem. 73, 2214-2217, (1999)
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Pritchard, D.E., et al., Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis 21, 2027-2033, (2000)
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Merck
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Merck 13,2781
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品名
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產(chǎn)地
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貨號
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規(guī)格
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單價
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備注
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環(huán)胞霉素A/環(huán)孢霉素A CYCLOSPORIN A
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SIGMA
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C3662
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5MG
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詢價
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