merck 559389-1MG SB203580,SB 203580,SB-203580
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產(chǎn)品名稱: merck 559389-1MG SB203580,SB 203580,SB-203580
產(chǎn)品型號(hào): merck 559389-1MG
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
merck 559389-1MG SB203580,SB 203580,SB-203580
merck 559389-1MG SB203580,SB 203580,SB-203580
的詳細(xì)介紹
merck 559389-1MG SB203580,SB 203580,SB-203580
SB 203580
產(chǎn)品說(shuō)明:SB203580也寫作SB 203580或SB-203580，是一種常用的p38 MAPK抑制劑。SB203580可以通透細(xì)胞，抑制p38 MAPK(p38 MAP kinase)，抑制后續(xù)MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通過(guò)抑制p38 MAPK，SB203580可以有效抑制一些炎癥因子(如IL-1β、TNF-α)誘導(dǎo)的部分信號(hào)轉(zhuǎn)導(dǎo)。SB203580選擇性抑制p38 MAPK，IC50為600 nM；對(duì)于JNK/SAPK和p44/42 MAPK(即Erk1/2)無(wú)顯著的抑制作用，IC50僅為100 μM。
SB203580分子量為377.43，分子式為C21H16N3FOS，CAS Number：152121-47-6。
MERCK相關(guān)產(chǎn)品資料：
559389 SB 203580 ( SB 203580 )
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
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Product number
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型號(hào)
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價(jià)格
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備注
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559389-1MG
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1 mg
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詢價(jià)
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現(xiàn)貨
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產(chǎn)品信息
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Form
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Thin film
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Primary Target
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P38MAPK
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Primary Target IC50
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34 nM
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Secondary target
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THP-1 (IC50 = 500-100 nM)
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Molar mass
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377.4
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Protect from Light
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Yes
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Cell permeable
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Yes
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Purity
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≥98% by HPLC
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Solubility
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DMSO
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Chemical formula
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C21H16N3OSF
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CAS number
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152121-47-6
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Store and ship information
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Storage
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-20°C
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Ship
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Ambient Temperature Only
Irritant
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**標(biāo)示
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S Phrase
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S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
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R Phrase
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R: 36/37/38
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